Depression can be devastating to family relationships, friendships, and the ability to work or go to school. Symptoms of depression vary from person to person. Some people have only a few symptoms, while others have many.

Symptoms can change over time and may include:

  • Persistent feelings of sadness, emptiness, or hopelessness (less common in elderly adults, children, and adolescents)
  • Feeling guilty, worthless, or helpless
  • Restlessness, worrying, or anxiety
  • Irritability or mood changes
  • Trouble sleeping, waking up too early, or oversleeping
  • Loss of interest in hobbies, activities, and social interaction
  • Feeling tired and generalized complaints, such as stomach ache, musculoskeletal complaints, and chronic pain
  • Inability to relax
  • Trouble focusing, remembering, or making decisions
  • Eating more or less than usual
  • Weight gain or weight loss
  • Loss of interest in sex
  • Physical symptoms that defy standard diagnosis and do not respond well to medical treatments
  • Thoughts of death or suicide (with or without suicide attempts)

Associated Conditions

Depression often coexists with other conditions, such as delivering a baby or chronic disease. The stress of coping with the disease may cause depression. Or depression may be caused by the disease itself or by medications used to treat the disease. Disorders commonly associated with depression include:

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